ea0029p1344 | Pituitary Basic | ICEECE2012
Jaita G.
, Zarate S.
, Ferraris J.
, Eijo G.
, Magri M.
, Gottardo M.
, Pisera D.
, Seilicovich A.
Our previous results demonstrate that estrogens increase the expression of death receptors TNFRI and Fas in the anterior pituitary and sensitize anterior pituitary cells to pro-apoptotic factors. c-FLIP is a protein that interacts with procaspases 8 and 10 modulating death receptor activity. In normal tissues, two isoforms of c-FLIP have been identified, the short isoform (c-FLIPs) and the long one (c-FLIPL). c-FLIPs has an anti-apoptotic action whereas c-FLIPL has either anti...